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DOI:10.1074/jbc.M710363200 - Corpus ID: 33469648
@article{Black2008TransformingGF, title={Transforming Growth Factor-$\beta$1 (TGF$\beta$1) Stimulates Connective Tissue Growth Factor (CCN2/CTGF) Expression in Human Gingival Fibroblasts through a RhoA-independent, Rac1/Cdc42-dependent Mechanism}, author={Samuel A. Black and Philip C. Trackman}, journal={Journal of Biological Chemistry}, year={2008}, volume={283}, pages={10835 - 10847}, url={https://api.semanticscholar.org/CorpusID:33469648}}
- S. Black, P. Trackman
- Published in Journal of Biological… 18 April 2008
- Medicine, Biology
Evidence is presented that Rho family GTPases Rac1 and Cdc42 are the principal mediators of the transforming growth factor-β1 (TGFβ1)-stimulated expression of CCN2/CTGF in primary human gingival fibroblasts.
57 Citations
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57 Citations
- M. BahammamS. BlackS. S. SumeM. AssaggafMichael FaibishP. Trackman
- 2013
Medicine, Biology
American journal of physiology. Cell physiology
A novel pathway in gingival fibroblasts in which inhibition of GSK-3β attenuates CCN2/CTGF expression is identified, consistent with previous studies performed in other cell models.
- 10
- PDF
- M. BahammamS. BlackS. S. SumeM. AssaggafMichael FaibishP. Trackman
- 2013
Biology, Medicine
Bahammam M, Black SA, Jr, Sume SS, Assaggaf MA, Faibish M, Trackman PC. Requirement for active glycogen synthase kinase-3 in TGF1 upregulation of connective tissue growth factor (CCN2/CTGF) levels in…
- Highly Influenced
- PDF
- Jung-Tsu ChenChen-Ying WangMin‐Huey Chen
- 2018
Medicine
Journal of the Formosan Medical Association…
- 18
- PDF
- Yuan ChangXinyi Wu
- 2009
Biology, Medicine
Molecular and Cellular Biochemistry
Real-time RT-PCR and Western blot analysis indicate that CTGF is critical to the fibrosis process in wounded human cornea, acting via upregulation and activation of JNK signaling pathway.
- 17
- King-Jean WuGuay-Fen HuangChun-Hao ChenHao-Hueng ChangYi‐Ting Deng
- 2014
Chemistry, Medicine
Journal of the Formosan Medical Association…
- 10
- PDF
- W. YangM. KuoC-M LiuY. DengH.-H. ChangJui-Chin Chang
- 2013
Medicine
Journal of dental research
Curcumin significantly abrogated the TGFβ1-induced CCN2 in HGFs by inhibiting the phosphorylations of Src, JNK, and Smad3, and curcumin potentially qualifies as a useful agent for the control of GO.
- 25
- Highly Influenced
- PDF
- S. HubchakErin E. SparksT. HayashidaH. W. Schnaper
- 2009
Medicine, Biology
American journal of physiology. Renal physiology
While both Rac1 and RhoA are rapidly activated in response to TGF-beta1 in human mesangial cells, only Rac1 activation enhances events that contribute to mesangia cell collagen expression, through a positive feedback loop involving PI3K.
- 49
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- Yi-Wen ChenWan-Hsien YangM. WongHao-Hueng ChangM. Yen-Ping Kuo
- 2012
Medicine
Journal of periodontology
The results of this study suggest that thrombin-induced CCN2 expression may occur through PAR1, reactive oxygen species, ASK1, and JNK signaling in HGFs and curcumin could effectively inhibit CCN 2 expression through JNK suppression.
- 15
- PDF
- W. YangY. DengYunsheng HsiehK. WuM. Kuo
- 2015
Biology, Medicine
Journal of dental research
The results indicated that NOX4-derived ROS play pivotal roles in activating Src kinase activity leading to the activation of canonical (Smad3) and noncanonical (JNK) cascades that cooperate to attain maximum CCN2 expression.
- S. KroeningSvetlana SolomovitchM. SachsB. WullichM. Goppelt‐Struebe
- 2009
Biology, Medicine
Nephrology, dialysis, transplantation : official…
Evidence is provided for a dual effect of HGF on CTGF regulation in human tubular epithelial cells: transient upregulation of CTGF in the absence of TGF-beta, which was related to alterations of cell morphology, and interference with T GF-beta-mediated CTGF induction after prolonged incubation.
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- PDF
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76 References
- S. BlackA. H. PalamakumburaM. StanP. Trackman
- 2007
Biology, Medicine
Journal of Biological Chemistry
Two mechanisms by which TGFβ1-stimulated CCN2/CTGF levels in human gingival fibroblasts resist down-regulation by PGE2 are identified: (i) cAMP cross-talk with MAPK pathways is limited in gingiver fibro Blasts; (ii) P GE2 activation of the EP3 prostanoid receptor stimulates the activation of JNK.
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- A. KantarcıS. Black P. Trackman
- 2006
Medicine, Biology
The Journal of pathology
The hypothesis that CTGF/CCN2 is expressed in human gingival fibromatosis tissues and contributes to this form of non‐drug‐induced gingiver overgrowth is investigated, suggesting that interactions between epithelial and connective tissues could contribute to gingivals fibrosis.
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- P. BonniaudP. MargettsK. AskK. FlandersJ. GauldieM. Kolb
- 2005
Medicine, Biology
The Journal of Immunology
KO and WT animals demonstrated a similar inflammatory response to overexpression of IL-1β indicating that inflammation must link to the Smad3 pathway, likely through TGF-β, to induce progressive fibrosis.
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- Keira L. WattsE. SampsonG. SchultzM. Spiteri
- 2005
Medicine
American journal of respiratory cell and…
The data suggest that Simvastatin can modify critical determinants of the profibrogenic machinery responsible for the aggressive clinical profile of IPF, and potentially prevents adverse lung parenchymal remodeling associated with persistent myofibroblast formation.
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- S. KubotaKazumi KawataT. YanagitaH. DoiT. KitohM. Takigawa
- 2004
Biology, Medicine
Journal of biochemistry
An abundance of connective tissue growth factor (CTGF/CCN2) in human platelets was discovered, which was released along with the coagulation process, and may be now regarded as one of the major functional components of platelets.
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- Gabriella LakosS. Takagawa John Varga
- 2004
Medicine, Biology
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- Yuan GaoJ. DickersonF. GuoJie ZhengYi Zheng
- 2004
Chemistry, Medicine
Proceedings of the National Academy of Sciences…
A first-generation small-molecule inhibitor of Rac GTPase targeting Rac activation by GEF, identified by a structure-based virtual screening of compounds that fit into a surface groove of Rac1 known to be critical for GEF specification, is reported.
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- A. HolmesD. Abraham A. Leask
- 2003
Medicine, Biology
Journal of Biological Chemistry
The constitutive overexpression of CTGF in SSc fibroblasts seems to be independent of TGFβ signaling but dependent at least in part on Sp1, suggesting that phosphorylation of Sp1 normally reduces Sp1 binding to DNA.
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- D. Brigstock
- 2003
Medicine, Biology
The Journal of endocrinology
The broad role played by the CCN family in basic and clinical endocrinology is illustrated and the relationship between CCN proteins and hormone action, skeletal growth, placental angiogenesis, IGF-binding proteins and diabetes-induced fibrosis is highlighted.
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- A. W. RachfalD. Brigstock
- 2003
Medicine, Biology
Hepatology research : the official journal of the…
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FIGURE 8. Overexpression of dominant-negative Rac1 or Cdc42, and not RhoA, leads to the near complete loss of CCN2/CTGF expression induced by TGF 1 in gingival cells. Gingival cell cultures were infected with…
Published in Journal of Biological Chemistry 2008
Transforming Growth Factor-β1 (TGFβ1) Stimulates Connective Tissue Growth Factor (CCN2/CTGF) Expression in Human Gingival Fibroblasts through a RhoA-independent, Rac1/Cdc42-dependent Mechanism
S. BlackP. Trackman
Figure 8 of 9